Finding an isekai anime with a female lead is a challenging task. As you would suspect, getting your hands on an isekai series with a male MC is extremely easy because there are tons of them. On the other hand, finding ANY isekai with a female MC—even if we are not considering their ratings—is difficult.
I spent many hours researching this topic and went to hell and back to find all available isekai anime with a female protagonist. And by that, I mean THE MAIN protagonist. Please make me know in the comments if you think I skipped some or find anything new so I can edit this article in the future. 🙂
My conclusion is that there are many awesome isekai light novels/manga with a female MC who is quietly waiting to be adapted into anime. I hope we will see that soon. I will make sure to update this list once we get some new ones worth watching.
For now, this is the 21 Best Isekai Anime Series With a Female MC!
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21. Fantastic Adventure Of Yohko: Leda
If you haven’t heard about this old isekai anime, don’t worry. It’s widely unknown with only 5k members on MAL. Fans of 80s anime are sure to appreciate it, though.
This 1-episode OVA aired in 1985 and follows the journey of Yohko, a young girl who gets transported to a mysterious realm that was separated from our realm a long time ago. To protect the people of her world, she has to close the path between the realms.
20. The Beauty Blogger
Adapted from a Chinese web novel written by Li Xiao, The Beauty Blogger is a shoujo donghua that debuted in 2018. Not only it is a solid isekai anime with a female MC but it’s also aimed at a female audience.
The heroine’s consciousness is trapped in a VR gamer after suffering a serious accident. There, she has to complete makeup-related tasks.
When I saw the first episode, I didn’t know what to think. The art is very distinctive and they used a lot of cutesy pastel colors. But if anything, it made it better.
I would recommend it to anyone who enjoys a blend of shoujo, soft reverse harem, and helpful makeup tips.
19. Haruka: Beyond the Stream of Time – A Tale of the Eight Guardians
Based on an otome game, Harukanaru follows an ordinary high school girl Akane who gets suddenly transported to a different world, along with her friends. There, she becomes a Dragon Priestess who is believed to be the savior of this world. But to do that, she has to fight demons with the aid of 8 sworn protectors.
While the story is as generic as it gets, it might be an enjoyable watch for avid reverse harem fans.
18. Adorable Food Goddess
Ye Jiayao is an exceptional cook who dreams of opening the best restaurant in Huai Song. Unfortunately, before she can make her dream come true, she has a mushroom poisoning accident and finds herself back in time, in the body of a young girl from Imperial China. What is worse, Ye Jiayao has no combat skills and her only strength is her divine cooking ability!
Adorable Food Goddess boasts gorgeous art and animation filled with scenes of yummy food. It mixes various genres but still manages to make it work. If you had enough of stupidly OP MCs, the MC of this series is different. She struggles and relies on her culinary prowess to survive in the dangerous world.
17. The Demonic King Who Chases His Wife
Su Luo’s story is everything but ordinary—she gets reincarnated at the right moment in medieval China. The good old useless Su Luo of medieval China becomes a powerful fighter with amazing magic whilst the demonic king accompanies her.
With only 10-11 minutes of actual anime time, this series is a short but solid romantic drama with a skilled heroine who doesn’t have to overly rely on anyone’s help. If you had enough of weak female MCs, you should try it.
16. Meiji Tokyo Renka
Tokyo Love Song is a time travel/isekai series that is a run-of-the-mill reverse harem.
In this show, a teenage girl from our time gets transported to Meiji-era Tokyo, where she proceeds to fall in love and collect an alarming amount of dashing young men around her.
Some people complain about its mediocrity and unsatisfying ending but the opinions are pretty split. I’ll let you decide!
15. Magic Knight Rayearth
One of the lesser-known isekai with multiple female MCs is Magic Knight Rayearth. The show ran between 1994 and 1995 with a total of two seasons and one special.
Magic Knight Rayearth follows three high school girls who get sucked into an alternate dimension, and need to defeat the main enemy oppressing the land, and then make it safely home.
Immerse yourself in the mysterious world of Cephiro as you follow these quirky girls on their journey of saving it.
14. Show By Rock!!
Show By Rock!! combines the unimaginable: isekai with music. As you can imagine, this show is definitely far from being generic.
It’s a story about a young talented guitarist who is absorbed by her phone and transported to an alternate world where music reigns supreme. She joins a band there and they go on a wacky adventure to save the world from evil.
13. In the Land of Leadale
In the Land of Leadale is an anime adaptation of Ceez’s light novel series that originally ran from 2010 to 2012.
Keina Kagami is a young girl fully dependent on life support because of the terrible state of her body.
One day, a power outage happens, and she dies in her sleep without knowing that. But instead of perishing, she wakes up in a world that is strikingly similar to the one from the VR game she used to play.
The anime series finished airing in March 2022, so it’s a pretty new isekai with a female MC.
Many consider it a hidden isekai gem. It has an enjoyable and extremely relaxing slice-of-life approach, so you don’t have to be too focused while watching it.
12. Kuma Kuma Kuma Bear
Yuna is a 15-year-old hardcore gamer, fully immersed in playing the VRMMO World Fantasy Online.
One ordinary day, she logs into the game as usual and accepts a bear costume from the game’s administrators. But not only does she ends up having OP stats, but she also gets transported to another world! While one would probably panic, Yuna embraces this change and decides to fully enjoy herself in this new world as an adventurer!
Cute, wholesome, and easy to consume. Did I forget anything? Just relax and enjoy!
11. The Saint’s Magic Power is Omnipotent
This series is an underrated hidden isekai gem released between Spring and Summer of 2021. It’s disappointing that it hasn’t gotten much recognition, but at the very least, I can promote it for all isekai admirers in this way.
Sei is summoned to another world against her will and then cast aside by the summoners, which rightfully makes her upset. However, after some thinking, she decides to make the best of what she has and, in fact, to make it a better life than she had at home.
10. Didn’t I Say to Make My Abilities Average in the Next Life?!
I don’t know about you but I wouldn’t want my abilities to be average in my next life. But this was the wish of the dying MC. She is then isekai’d but she is still too OP because the world she is born in has a vast difference between the weakest and the strongest beings.
Add this to your list of light watches as its subgenre is ‘cute girls doing cute stuff’. You know what you are getting yourself into.
9. Mysterious Play
Do shoujo, reverse harem, and isekai appeal to you? Then keep an eye out since this could be your next favorite!
The heroine is isekai’d as a priestess who is expected to save the world by summoning the kingdom’s protector god. But to do so, she has to gather the god’s seven Celestial Warriors first.
8. The Twelve Kingdoms
This is a series with a strong female protagonist, fantastic worldbuilding, and a unique plot set in a gorgeous, mystical world.
Youko Nakajima is a high school girl whose only wish is to be ‘normal’. Despite her attempts to fit in high school, she has never blended in because of her fiery red hair.
One day, Yoko is accosted at school by a handsome blonde man called Keiki who wants to swear allegiance to her. Before she knows it, monsters are attacking her, she’s being defended by Keiki, and then Yoko and her 2 friends are transported to another world. Thus begins her journey in the magical land of the 12 kingdoms!
7. The Vision of Escaflowne
Escaflowne is a gorgeous and fascinating fantasy adventure from the 1990s. It’s a classic isekai that was done before it got popular. This anime is a blend of mecha, romance, and action, with beautiful music to match.
Hitomi, the main character, gets pulled into an alternative world that is on the verge of war. This is due to a beardy emperor with intentions to manipulate fate according to his whim. Now it’s up to Hitomi and her new allies to stand up to the dark forces.
6. Jahy-sama Will Not Be Defeated!
After a magical girl destroys the Dark Realm, Jahy, the second-in-command in the Dark Realm, finds herself in the human world, in the body of a little girl.
With its cute, wholesome, and hilarious moments, it is sure to put a smile on your face. 🙂
5. Ascendance Of A Bookworm
Ascendance Of A Bookworm is among the highest-rated anime on this list with a score of 8.01 on MAL.
Urano, a young Japanese soon-to-be librarian, dies in an earthquake. As she draws her last breath, she wishes to be able to read more books in her next life.
Right after, she gets reincarnated in a medieval world as a 5-year-old girl named Myne. There, she learns that books are scarce and only provided to a few elite nobles. Even that can’t discourage Mayne, and she is determined to make books by herself!
Right away, it’s clear that this isekai is going to do something new and different with the isekai genre. Which is a great thing if you ask me!
4. I’ve Been Killing Slimes for 300 Years and Maxed Out My Level
A corporate slave passes away from exhaustion and reincarnates in a fantasy world as an immortal being. She lives there peacefully, killing slimes for at least three centuries. However, this stereotype is abruptly interrupted when she realizes that she has reached level 99—the maximum possible level—from slimes alone. The rumors about it spread quickly and many people start to seek her for all kinds of reasons!
We can all relate to the MC’s desires. Instead of the frantic lifestyle that many of us have, we see her living a tranquil and relaxing life. You want to watch this anime when you want to have a good time and laugh. Don’t expect any flashy action.
3. So I’m A Spider, So What?
So I’m A Spider, So What? has a refreshing take on isekai. It starts as your typical isekai story with the whole class resurrected in an RPG-like world but while all of the MC’s classmates are reborn with a prestigious background, she is resurrected as the weakest spider.
Kumoko’s journey is full of struggles as she tries to navigate through this harsh and unrelenting environment, but that is the enjoyable part of the series that makes it stand out. If she wants to make something of this new life, she’ll have to adjust not only to the new world but also to her new form.
2. My Next Life As A Villainess
My Next Life As A Villainess is an entertaining isekai series that proves that reverse harem doesn’t have to be mindless and that isekai can be unique. It’s also my personal favorite isekai anime with a female MC, I really adore Bakarina!
The heroine is a young girl who accidentally bumps her head and regains memories of her past life as an otaku. She quickly realizes that she was reborn in the world of Fortune Lover—one of the games she had used to play! Unfortunately, the character she was reincarnated into is the game’s main antagonist!
Watching the MC plan various schemes to prevent the ‘doom routes’ that come with being an antagonist is the definition of fun.
Are you a fan of romantic comedies with awesome writing? Then go watch Villainess right now!
And the title ranking on our list goes to Inuyasha as it’s one of the most popular & widely-recognized isekai anime series with a female MC.
According to IMDB, It’s a story about a teenage girl who periodically travels back in time to feudal Japan to help a young half-demon recover the shards of a jewel of great power.
The series has a MAL score of 7,85 and more than 711k members. It’s one of the isekai shows that were made before it was cool. Inuyasha offers a gripping love story that blends pretty well with shounen.
Even though some say that Inuyasha is the main character, I think that Kagome (the girl) is the MC. She’s also the one who travels to the other world.
Hi, my name is Mia, and I am the founder of 9 Tailed Kitsune. I am a big fan of esports, games, and anime. When I was around 7 years old, Phantom Thief Jeanne sparked my fascination for anime, and it has never faded!