26 Best Isekai Anime With a Female MC

Finding a good isekai anime with a female MC can be a challenging task. While it is easy to find isekai series with male protagonists, there are relatively few options for female MCs. This can be frustrating for both fans and writers alike, and I totally get it.

After spending countless hours researching this topic, I’ve compiled a list of all available isekai anime series with a female protagonist. Please let me know in the comments if you think I’ve missed any or if you come across any new series that should be added.

My conclusion is that there are many fantastic isekai light novels and manga with female MCs that are waiting to be adapted into anime. Hopefully, we’ll see more adaptations in the future.

So without further ado, here are the 26 best isekai anime series with a female MC!

🔔 As of 09/26/2023, I have updated this list to include additional isekai anime series with a female protagonist that have aired. It’s exciting to see more representation of female MCs in this genre, and I will continue to update this list as new series are released.

Disclaimer: This post contains affiliate links. If you use these links to buy something, I may earn a small commission, without any extra cost to you. As an Amazon Associate, I earn from qualifying purchases. Thank you!

26. The Most Heretical Last Boss Queen: From Villainess to Savior

If you’re a fan of the recent surge in otome/villainess-style anime and have ever found yourself frustrated with the usual anime tropes, The Most Heretical Last Boss Queen might just be your next favorite series. This anime breaks away from the norm by addressing those common annoyances head-on. Say goodbye to characters making illogical decisions, and hello to thoughtful communication that could solve most problems.

In this anime, we join Pride, the kingdom’s firstborn princess, as she’s hit with a wave of memories from a Japanese girl. It turns out she’s been reborn as the game’s future villainess, but she’s not having it. Watch as she takes charge, tries to change her fate, and rewrites the story for a brighter future.

25. No Game No Life

No Game No Life is an isekai classic at this point. If you haven’t seen it, you are missing out on one of the best in the genre. In this anime, we follow a likable sibling duo, Sora and Shiro, who get transported to a world where everything is decided by games. Yes, even world politics and conflicts are settled through gaming showdowns!

Now, Shiro, Sora’s little sister, is no ordinary girl. She’s a gaming genius with an IQ that’s off the charts. Together, they form an unbeatable team, combining Sora’s wits and Shiro’s strategic brilliance to conquer this new fantasy realm.

Although the anime has two protagonists, Shiro certainly isn’t just some sidekick. She’s one of the main characters, holding her own alongside her big brother in these epic gaming battles.

24. Fantastic Adventure Of Yohko: Leda

If you haven’t heard about this old isekai anime, don’t worry. It’s widely unknown with only 5k members on MAL. Fans of 80s anime are sure to appreciate it, though.

This 1-episode OVA aired in 1985 and follows the journey of Yohko, a young girl who gets transported to a mysterious realm that was separated from our realm a long time ago. To protect the people of her world, she has to close the path between the realms.

23. The Beauty Blogger

Adapted from a Chinese web novel written by Li Xiao, The Beauty Blogger is a shoujo donghua that debuted in 2018. Not only it is a solid isekai anime with a female MC but it’s also aimed at a female audience.

The heroine’s consciousness is trapped in a VR gamer after suffering a serious accident. There, she has to complete makeup-related tasks.

When I saw the first episode, I didn’t know what to think. The art is very distinctive and they used a lot of cutesy pastel colors. But if anything, it made it better.

I would recommend it to anyone who enjoys a blend of shoujo, soft reverse harem, and helpful makeup tips.

22. Haruka: Beyond the Stream of Time – A Tale of the Eight Guardians

Based on an otome game, Harukanaru follows an ordinary high school girl Akane who gets suddenly transported to a different world, along with her friends. There, she becomes a Dragon Priestess who is believed to be the savior of this world. But to do that, she has to fight demons with the aid of 8 sworn protectors.

While the story is as generic as it gets, it might be an enjoyable watch for avid reverse harem fans.

21. Adorable Food Goddess

Ye Jiayao is an exceptional cook who dreams of opening the best restaurant in Huai Song. Unfortunately, before she can make her dream come true, she has a mushroom poisoning accident and finds herself back in time, in the body of a young girl from Imperial China. What is worse, Ye Jiayao has no combat skills and her only strength is her divine cooking ability!

Adorable Food Goddess boasts gorgeous art and animation filled with scenes of yummy food. It mixes various genres but still manages to make it work. If you had enough of stupidly OP MCs, the MC of this series is different. She struggles and relies on her culinary prowess to survive in the dangerous world.

20. Why Raeliana Ended Up at the Duke’s Mansion

When Park Eunha dies, she wakes up as Raeliana, a rich girl in a world from a novel she once read. But she’s not the main character; she’s just a plot device who will get unalived by her fiancé.

Since Raeliana is not happy with this fate, she targets the story’s hero, Duke Noah, to change the plot. She offers to help him if he pretends to be her fiancé, but he’s not easy to deal with!

Why Raeliana Ended Up at the Duke’s Mansion was adapted from a well-developed romance manhwa that offers a complex but cheesy story.

The writing is appealing, with a well-thought-out story and smart villains that don’t act stupid.

Overall, it’s a good watch for fans of isekai, romance, and intrigue.

19. The Demonic King Who Chases His Wife

Su Luo’s story is everything but ordinary—she gets reincarnated at the right moment in medieval China. The good old useless Su Luo of medieval China becomes a powerful fighter with amazing magic whilst the demonic king accompanies her.

With only 10-11 minutes of actual anime time, this series is a short but solid romantic drama with a skilled heroine who doesn’t have to overly rely on anyone’s help. If you had enough of weak female MCs, you should try it.

18. Meiji Tokyo Renka

Tokyo Love Song is a time travel/isekai series that is a run-of-the-mill reverse harem.

In this show, a teenage girl from our time gets transported to Meiji-era Tokyo, where she proceeds to fall in love and collect an alarming amount of dashing young men around her. 

Some people complain about its mediocrity and unsatisfying ending but the opinions are pretty split. I’ll let you decide!

17. Magic Knight Rayearth

One of the lesser-known isekai with multiple female MCs is Magic Knight Rayearth. The show ran between 1994 and 1995 with a total of two seasons and one special.

Magic Knight Rayearth follows three high school girls who get sucked into an alternate dimension and need to defeat the main enemy oppressing the land, and then make it safely home.

Immerse yourself in the mysterious world of Cephiro as you follow these quirky girls on their journey to save it.

16. Show By Rock!!

Show By Rock!! combines the unimaginable: isekai with music. As you can imagine, this show is definitely far from being generic.

It’s a story about a young talented guitarist who is absorbed by her phone and transported to an alternate world where music reigns supreme. She joins a band there and they go on a wacky adventure to save the world from evil.

15. In the Land of Leadale

In the Land of Leadale is an anime adaptation of Ceez’s light novel series that originally ran from 2010 to 2012.

Keina Kagami is a young girl fully dependent on life support because of the terrible state of her body.

One day, a power outage happens, and she dies in her sleep without knowing that. But instead of perishing, she wakes up in a world that is strikingly similar to the one from the VR game she used to play.

The anime series finished airing in March 2022, so it’s a pretty new isekai with a female MC.

Many consider it a hidden isekai gem. It has an enjoyable and extremely relaxing slice-of-life approach, so you don’t have to be too focused while watching it.

14. Kuma Kuma Kuma Bear

Yuna is a 15-year-old hardcore gamer, fully immersed in playing the VRMMO World Fantasy Online.

One ordinary day, she logs into the game as usual and accepts a bear costume from the game’s administrators. Not only does she end up having OP stats, but she also gets transported to another world! While one would probably panic, Yuna embraces this change and decides to fully enjoy herself in this new world as an adventurer!

Cute, wholesome, and easy to consume. Did I forget anything? Just relax and enjoy!

13. The Saint’s Magic Power is Omnipotent

This series is an underrated hidden isekai gem released between the Spring and Summer of 2021. It’s disappointing that it hasn’t gotten much recognition, but at the very least, I can promote it for all isekai admirers in this way.

Sei is summoned to another world against her will and then cast aside by the summoners, which rightfully makes her upset. However, after some thinking, she decides to make the best of what she has and, in fact, to make it a better life than she had at home.

12. Didn’t I Say to Make My Abilities Average in the Next Life?!

I don’t know about you but I wouldn’t want my abilities to be average in my next life. But this was the wish of the dying MC. She is then isekai’d but she is still too OP because the world she is born in has a vast difference between the weakest and the strongest beings.

Add this to your list of light watches as its subgenre is ‘cute girls doing cute stuff’. You know what you are getting yourself into.

11. Mysterious Play

Do shoujo, reverse harem, and isekai appeal to you? Then keep an eye out since this could be your next favorite!

The heroine is isekai’d as a priestess who is expected to save the world by summoning the kingdom’s protector god. But to do so, she has to gather the god’s seven Celestial Warriors first.

10. The Magical Revolution of the Reincarnated Princess and the Genius Young Lady

Is it just me, or are isekai stories about a noble’s daughter engaged to a prince, only to have the engagement broken off in favor of a commoner girl, becoming more common?

That being said, The Magical Revolution of the Reincarnated Princess and the Genius Young Lady puts a unique yuri spin on this trope, making it less generic and instead, it’s pure joy and wholesomeness.

To compare it to the more popular Lycoris Recoil, the main duo shares similar dynamics and personalities, with one character being a genki girl and the other a kuudere.

9. I’m the Villainess, So I’m Taming the Final Boss

I’m the Villainess, So I’m Taming the Final Boss provides a perfect mix of isekai and comedy. If you’ve seen the more popular Hamefura, the premise is almost identical. And while the execution was different, it still gives off very similar lighthearted and heart-warming vibes.

You can’t help but fall in love with Aileen, the protagonist, who is beautiful and caring but also fierce and independent. She works hard and is unflinching in her principles, fighting evil and defending the people she loves from harm.

8. The Twelve Kingdoms

This is an older isekai anime series with a strong female MC, fantastic worldbuilding, and a unique plot set in a gorgeous, mystical world.

Youko Nakajima is a high school girl whose only wish is to be ‘normal’. Despite her attempts to fit in high school, she has never blended in because of her fiery red hair.

One day, Yoko is accosted at school by a handsome blonde man called Keiki who wants to swear allegiance to her. Before she knows it, monsters are attacking her, she’s being defended by Keiki, and then Yoko and her 2 friends are transported to another world. Thus begins her journey in the magical land of the 12 kingdoms!

7. The Vision of Escaflowne

Escaflowne is a gorgeous and fascinating fantasy adventure from the 1990s. It’s a classic isekai that was done before it got popular. This anime is a blend of mecha, romance, and action, with beautiful music to match.

Hitomi, the main character, gets pulled into an alternative world that is on the verge of war. This is due to a beardy emperor with intentions to manipulate fate according to his whim. Now it’s up to Hitomi and her new allies to stand up to the dark forces.

6. Jahy-sama Will Not Be Defeated!

After a magical girl destroys the Dark Realm, Jahy, the second-in-command in the Dark Realm, finds herself in the human world, in the body of a little girl.

With its cute, wholesome, and hilarious moments, it is sure to put a smile on your face. 🙂

5. Ascendance Of A Bookworm

Ascendance Of A Bookworm is among the highest-rated anime on this list with a score of 8.01 on MAL.

Urano, a young Japanese soon-to-be librarian, dies in an earthquake. As she draws her last breath, she wishes to be able to read more books in her next life.

Right after, she gets reincarnated in a medieval world as a 5-year-old girl named Myne. There, she learns that books are scarce and only provided to a few elite nobles. Even that can’t discourage Mayne, and she is determined to make books by herself!

Right away, it’s clear that this isekai is going to do something new and different with the isekai genre. Which is a great thing if you ask me!

4. I’ve Been Killing Slimes for 300 Years and Maxed Out My Level

A corporate slave passes away from exhaustion and reincarnates in a fantasy world as an immortal being. She lives there peacefully, killing slimes for at least three centuries. However, this stereotype is abruptly interrupted when she realizes that she has reached level 99—the maximum possible level—from slimes alone. The rumors about it spread quickly and many people start to seek her for all kinds of reasons!

We can all relate to the MC’s desires. Instead of the frantic lifestyle that many of us have, we see her living a tranquil and relaxing life. You want to watch this anime when you want to have a good time and laugh. Don’t expect any flashy action.

3. So I’m A Spider, So What?

So I’m A Spider, So What? has a refreshing take on isekai. It starts as your typical isekai story with the whole class resurrected in an RPG-like world but while all of the MC’s classmates are reborn with a prestigious background, she is resurrected as the weakest spider.

Kumoko’s journey is full of struggles as she tries to navigate through this harsh and unrelenting environment, but that is the enjoyable part of the series that makes it stand out. If she wants to make something of this new life, she’ll have to adjust not only to the new world but also to her new form.

2. My Next Life As A Villainess

My Next Life As A Villainess is an entertaining isekai series that proves that reverse harem doesn’t have to be mindless and that isekai can be unique. It’s also my personal favorite isekai anime with a female MC, I really adore Bakarina!

The heroine is a young girl who accidentally bumps her head and regains memories of her past life as an otaku. She quickly realizes that she was reborn in the world of Fortune Lover—one of the games she had used to play! Unfortunately, the character she was reincarnated into is the game’s main antagonist!

Watching the MC plan various schemes to prevent the ‘doom routes’ that come with being an antagonist is the definition of fun.

Are you a fan of romantic comedies with awesome writing? Then go watch Villainess right now!

1. Inuyasha

The top spot on our list is claimed by Inuyasha, a widely recognized and highly popular isekai anime series featuring a female main character.

According to IMDB, It’s a story about a teenage girl who periodically travels back in time to feudal Japan to help a young half-demon recover the shards of a jewel of great power.

The series has a MAL score of 7,85 and more than 711k members. It’s one of the isekai shows that were made before it was cool. Inuyasha offers a gripping love story that blends pretty well with shounen.

Even though some claim that Inuyasha is the main character, I think that Kagome (the girl) is the MC. She’s also the one who travels to the other world.